Synthesis curcumin-cyclodextrin complex and curcumin-phospholipid complex using supercritical CO2 technical

Project leader's name
Dr. Phan Thanh Thao
Project duration
2013 - 2015
́Project’s budget
600.000.000 VN dong
Classify
Excellent
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Goal and objectives of the project

Preparationofcurcumin-cyclodextrin and curcumin-phospholipid complex using supercritical CO2 technical (RESS-SEDS process). Here we report the synthesis of curcumin compexation in clean condition using CO2 supercritical as reaction media with high synthesis efficient.

Main results

Theoretical results: Here we report the synthesis of curcumin compexation with cyclodextrin and phospholipid in clean condition using CO2 supercritical as reaction media. The reaction parameters were varied and investigated. Complexation product was mearsured the water solubility, structure and the characteristics by UV-Vis absorption, FTIR, DSC, HPLC-ESI-MS, 1H NMR. Results showed the significant improvement in synthesis efficient and product properties point of view.

Curcumin-cyclodextrin complex: High synthesis efficient was archives,the water solubility of complexed curcumin is approximately 300 times enhanced compared to that of intrinsic curcumin. High stability of the curcumin as shown in the sample of the complex indicating a very good.

Curcumin-phospholipid complex: Based on the calculation, the water solubility of complexed curcumin is approximately 4000 times enhanced compared to that of intrinsic curcumin. Moreover, in the complex there is the presence of curcumin nanoparticles with particles size approximately 100 nm. FE-SEM image indicates, that curcumin was encapsulated on phosphatidylcholine membrane and lyposome structure was formed.

Applied results: Curcumin is widely used as a spice, food preservative, and flavoring and coloring agent. Evidence suggests curcumin has the potential to prevent or treat various pathophysiological processes, includingcardiovascular disease, carcinogenesis, wound healing and inflammation. However, the intrinsic low water solubility and low stability are two obstacles that inhibit the high activated property of curcumin. In this point of view, supercritical CO2 (scCO2) is ideal media for drug-carrier preparation and modification. Compare to conventional organic solvent, SC-CO2 is relative “green solvent” due to it nonflameble, relatively non-toxic and relatively inert. We clarify the condition for the synthesis complex in scCO2 solvent and enhance efficient.

Novelty and actuality and scientific meaningfulness of the results
  • Results of the research is successful synthesis curcumin-cyclodextrin, curcumin-phospholipid with supercritical CO2 technique. In Vietnam, the use scCO2 reaction solvent is still very new, only used in the extraction process. Research synthesisternary complex curcumin-β-CD-lysine from using curcumin-lysinate used scCO2 is a solvent for the reaction is a new direction. Currently in the world there is no announced performance and product characteristics for this research.
  • The complex synthesized in scCO2 media, that promoting the pharma pharmacology of curcumin advantages by improving the solubility, durability.
Products of the project

Scientific papers in referenced journals (list):

  • 01 papers published in J. Chemistry
  • 01reportsonthe international conferences (ISBN)

Other products (if applicable): 01 Master thesis

Recommendations

Suggestting the research continue to implement the pilot in order to perfect the technology research at a larger scale to production test applications.

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