Investigation on the isolation of bioactive secondary metabolites from some microalgaes living in Central coast of Vietnam (from North Central to Middle Central Coast)

Project leader's name
Dr. Nguyen Thi Minh Hang
Research hosting institution
Institute of Marine Biochemistry
Project duration
2016 - 2018
́Project’s budget
3,800 million VND
Classify
Excellent
Goal and objectives of the project

- Search on the bioactive secondary metabolites from marine microalgaes with antimicrobial activity, cytotoxic activity and antioxidant activity.

Main results

- Theoretical results:
+ 31 strains of microalgaes, which were similar to symbiotic microalgae of Symbiodinium genus, have been isolated from 37 species of coral and 40 samples of sponges from Quang Binh, Quang Tri , Hue and Quang Nam.SHM8 strains was identified as Symbiodinium goreaui. Two strains SH3 and HM1 were identified belong to Symbiodinium genus.
+ 36 different compounds were isolated form seven microalges species. Their structures were identied by NMR and MS spectra. One of these compound have been isolated from the nature for the first time.
+ Investigated of biological activities of pure compounds and found that 12 compounds showed antimicrobial activity and 07 compounds showed cytotoxic activity, especially compounds DTH1 and NOE1exhibited singificant activity on both of tested bioassays.

Some images of the project:

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Novelty and actuality and scientific meaningfulness of the results

+ 06 microalgae species including Dunaliellatertiolecta, Nannochloropsis oculata, Chaetoceros muelleri, Tetraselmis convolutae, Isochrysis galbanaandSchizochytrium mangroveiwere investigated on the chemical constituents and biological activity for the first time.
+ Compound phytyl hexadeca-4,7-10,13-tetraenoate (TC12) have been isolated from the nature for the first time.

Products of the project

- Scientific papers in referred journals (list):
International journals:
+ Nguyen Thi Tu Oanh, Tran Huu Giap, Le Nguyen Thanh, Vu Thi Kim Oanh, Dang Diem Hong, Ngo Thi Hoai Thu, Nguyen Van Hung, Chau Van Minh and Nguyen Thi Minh Hang, CHEMICAL CONSTITUENTS OF Nannochloropsis oculata, Chemistry of Natural Compounds (accepted).
+ Nguyen Thi Minh Hang, TranHuu Giap, Le Nguyen Thanh, Dang Diem Hong, Ngo Thi Hoai Thu and Chau Van Minh, CHEMICAL CONSTITUENTS OF MICROALGAE Tetraselmis convolutae, Chemistry of Natural Compounds (accepted).
+ Nguyen Thi Minh Hang,Tran Huu Giap, Le Nguyen Thanh, Nguyen Thi Tu Oanh, Dang Diem Hong, and Chau Van Minh, METABOLITES FROM MICROALGAE Schizochytrium mangrovei, Chemistry of Natural Compounds (accepted).
Domestic journals:
+ Nguyen Thi Tu Oanh, Nguyen Thi Minh Hang, Ha Thi Thoa, Le Nguyen Thanh, Tran Huu Giap, Vu Thi Kim Oanh, Nguyen Van Hung, Dang Diem Hong, Ngo Thi Hoai Thu, Chau Van Minh(2017), Chemical constituents of the marine microalgae Dunaliella tertiolecta, Vietnam journal of Chemistry, 55(6e), 66-71
+ Tran Huu Giap, Ha Thi Thoa, Vu Thi Kim Oanh, Nguyen Thi Tu Oanh, Nguyen Van Hung, Chau Van Minh, Dang Diem Hong, Ngo Thi Hoai Thu, Nguyen Thi Minh Hang, Le Nguyen Thanh (2017), Chemical constituents from the marine microalgae Chlorella vulgaris, Vietnam journal of Chemistry, 55(6e), 34-37
+ Dang Diem Hong, Pham Van Nhat, Hoang Thi Huong Quynh, Luu Thi Tam, Ngo Thị Hoai Thu, Nguyen Cam Ha, Hoang Thị Lan Anh, Nguyen Hoai Nam, Nguyen Thi Minh Hang, Chau Van Minh (2017), Study on biocharacteristics of Symbiodinium sp. isolated from soft coral in coastal water of Quang Nam, south central Vietnam, Tạp chí sinh học, 39(3):467-475.
+ Nguyen Thi Minh Hang, Tran Huu Giap, Ha Thi Thoa, Dinh Ngoc Thuc, Nguyen Quoc Vuong, Chau Van Minh, Le Nguyen Thanh (2017), Study on the chemical constituents of Chlorella vulgaris Beijerinck, Vietnam Journal of Pharmacy, 10/1017 (No 498), 58-61.
- Technological products (describe in details: technical characteristics, place):
+ Scientific records of selected microalgaes.
+ 07 reports on the isolation and structure isolation of isolated compounds from selected microalgaes.
+ 06 reports on the biological activity of extracts and isolated compounds from selected microalgaes.
These products are stored at the Center for Drug Research and Development - Institute of Marine Chemistry

Recommendations

Continuation of the investigation on the chemical constituents and biological activity of other marine microalgaes, especiallyastrophic microalgaes.

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